Michael A. Lynes Laboratory

Claire Peterson
Lynes Lab

Distinguishing Inflammatory Diseases Using a Grating-Coupled Fluorescence Plasmonic Biomarker Signature Assay

Host and pathogen factors that influence variability of Mycobacterium tuberculosis lipid body content in sputum from patients with tuberculosis: an observational study/ https://www.sciencedirect.com/science/article/pii/S2666524724001083?via%3Dihub

Dr. Eric Joyce
University of Pennsylvania
Host: Jelena Erceg

From tangled mess to ordered structure: unraveling the mechanisms of 3D genome organization

My presentation will discuss our work to understand the mechanisms of genome organization. We leverage the HiDROplatform to identify and explore a noncanonical role of GSK3A, offering insights into chromatin dynamics and potential therapeutic strategies for cohesin-related disorders

About Dr. Joyce:
Eric Joyce, PhD, is an Associate Professor of Genetics and core member of the Epigenetics Institute at the Universityof Pennsylvania. Dr. Joyce conducted his postdoctoral training with Dr. Ting Wu at Harvard Medical School, where heco-developed a novel type of FISH probe called Oligopaints. Dr. Joyce’s lab continues to develop and utilize newtechnologies to interrogate chromosome structure at single-cell resolution. His lab aims to understand how thestructure of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctionalorganization contributes to genome instability and disease. Most recently, his lab developed HiDRO, an automatedimaging pipeline to identify novel proteins that regulate genome organization.

Publications:
https://pubmed.ncbi.nlm.nih.gov/37438531/

https://pubmed.ncbi.nlm.nih.gov/36449519/

Joyce Lab